Reducing loss to follow up during treatment for drug-resistant tuberculosis

In this issue of the European Respiratory Journal, Law et al summarise, in their systematic literature review, the evidence for measures that minimise loss to follow-up during treatment of drug-resistant TB in adults. The synthesis of results suggests that supplementing standard care with psychosocial, educational or material support decreased loss to follow-up (defined as treatment interruption of two or more months). The greatest effect was seen when daily home visits were combined with directly observed therapy (DOT)

A general low frequency acoustic radiation capability for NASTRAN

A new capability called NASHUA is described for calculating the radiated acoustic sound pressure field exterior to a harmonically-excited arbitrary submerged 3-D elastic structure. The surface fluid pressures and velocities are first calculated by coupling a NASTRAN finite element model of the structure with a discretized form of the Helmholtz surface integral equation for the exterior fluid. After the fluid impedance is calculated, most of the required matrix operations are performed using the general matrix manipulation package (DMAP) available in NASTRAN. Far field radiated pressures are then calculated from the surface solution using the Helmholtz exterior integral equation. Other output quantities include the maximum sound pressure levels in each of the three coordinate planes, the rms and average surface pressures and normal velocities, the total radiated power and the radiation efficiency. The overall approach is illustrated and validated using known analytic solutions for submerged spherical shells subjected to both uniform and nonuniform applied loads

Tetrisation of triangular meshes and its application in shape blending

The As-Rigid-As-Possible (ARAP) shape deformation framework is a versatile technique for morphing, surface modelling, and mesh editing. We discuss an improvement of the ARAP framework in a few aspects: 1. Given a triangular mesh in 3D space, we introduce a method to associate a tetrahedral structure, which encodes the geometry of the original mesh. 2. We use a Lie algebra based method to interpolate local transformation, which provides better handling of rotation with large angle. 3. We propose a new error function to compile local transformations into a global piecewise linear map, which is rotation invariant and easy to minimise. We implemented a shape blender based on our algorithm and its MIT licensed source code is available online

A review of routing protocols in wireless body area networks

Recent technological advancements in wireless communication, integrated circuits and Micro-Electro-Mechanical Systems (MEMs) has enabled miniaturized, low-power, intelligent, invasive/ non-invasive micro and nano-technology sensor nodes placed in or on the human body for use in monitoring body function and its immediate environment referred to as Body Area Networks (BANs). BANs face many stringent requirements in terms of delay, power, temperature and network lifetime which need to be taken into serious consideration in the design of different protocols. Since routing protocols play an important role in the overall system performance in terms of delay, power consumption, temperature and so on, a thorough study on existing routing protocols in BANs is necessary. Also, the specific challenges of BANs necessitates the design of new routing protocols specifically designed for BANs. This paper provides a survey of existing routing protocols mainly proposed for BANs. These protocols are further classified into five main categories namely, temperature based, cross-layer, cluster based, cost-effective and QoS-based routing, where each protocol is described under its specified category. Also, comparison among routing protocols in each category is given. © 2013 ACADEMY PUBLISHER

Virginity and Guilt Differences Between Men and Women

In this research, the authors measured the levels of sexual guilt between two groups of people on multiple levels, virgins and nonvirgins, by gender. The differences between men and women when it comes to virginity will also be studied. Based on the sample size of college students, N = 364. College students (N=364) completed a 34-item online survey of questions that measure guilt levels. Ten out of the twenty questions are demographic questions, such as: age, ethnicity, religion, year, etc. The other questions were a combination of Likert scaled questions and open ended responses. We predicted that females will produce more guilt compared to males after they lose their virginity. The researchers found that females do produce sexual guilt compared to males and high scores of religiosity also produce higher levels of sexual guilt for females

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab

Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition. Case presentation: We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital. Conclusion: Rituximab, the efficacy of which has thus far been examined predominantly in patients outside the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease can benefit from intensive care